A memory subsystem employs spare memory cells external to one or more memory devices. In some embodiments, a processing system uses the spare memory cells to replace individual selected cells at the protected memory, whereby the selected cells are replaced on a cell-by-cell basis, rather than exclusively on a row-by-row, column-by-column, or block-by-block basis. This allows faulty memory cells to be replaced efficiently, thereby improving memory reliability and manufacturing yields, without requiring large blocks of spare memory cells.