A micro-architecture may provide a hardware and software co-designed dynamic binary translation. The micro-architecture may invoke a method to perform a dynamic binary translation. The method may comprise executing original software code compiled targeting a first instruction set, using processor hardware to detect a hot spot in the software code and passing control to a binary translation translator, determining a hot spot region for translation, generating the translated code using a second instruction set, placing the translated code in a translation cache, executing the translated code from the translated cache, and transitioning back to the original software code after the translated code finishes execution.