Memory page de-duplication in a computer system that includes a plurality of virtual machine partitions managed by a hypervisor, where each virtual machine is assigned a different dedicated memory partition, may include: identifying, by the hypervisor, a plurality of identical memory pages in memory of one or more dedicated memory partitions; assigning, by the hypervisor, one of the identical memory pages as a master page; mapping, for each virtual machine having an identical memory page, each of the identical memory pages to the master page; and directing, by the hypervisor, reads of the memory page to the master page.