Invention Grant
- Patent Title: Triazolopyridine JAK inhibitor compounds and methods
- Patent Title (中): 三唑并吡嗪JAK抑制剂化合物及方法
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Application No.: US14049458Application Date: 2013-10-09
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Publication No.: US09434732B2Publication Date: 2016-09-06
- Inventor: Bing-Yan Zhu , Michael Siu , Steven R. Magnuson , Richard Pastor , He Haiying , Xiao Yisong , Zheng Jifu , Xu Xing , Zhao Junping , Christopher Hurley , Jun Liang , Wendy Liu , Joseph P. Lyssikatos
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Tamara A. Kale
- Main IPC: C07D471/02
- IPC: C07D471/02 ; C07D487/04 ; C07D471/04 ; A61K31/437 ; A61K31/496 ; A61K31/5377

Abstract:
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.
Public/Granted literature
- US20140038939A1 TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS Public/Granted day:2014-02-06
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