公开(公告)号：US20180222882A1

公开(公告)日：2018-08-09

申请号：US15801201

申请日：2017-11-01

申请人： Genentech, Inc.

发明人： Benjamin Fauber ,  Monique Bodil van Niel ,  Andrew Cridland ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D401/14 ,  C07D491/107 ,  A61P19/02 ,  A61P25/28 ,  A61P17/06 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06

CPC分类号： C07D401/04 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D491/107

摘要： Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, A, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20170137393A1

公开(公告)日：2017-05-18

申请号：US15199447

申请日：2016-06-30

申请人： Genentech, Inc.

发明人： Monique Bodil van Niel ,  Benjamin Fauber ,  Emanuela Gancia ,  Simon Gaines ,  Alberto Gobbi ,  Christopher Hurley ,  Tammy Ladduwahetty ,  Olivier Rene ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC分类号： C07D279/02 ,  C07D417/12 ,  C07D417/10

CPC分类号： C07D279/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08

摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

公开(公告)号：US09434732B2

公开(公告)日：2016-09-06

申请号：US14049458

申请日：2013-10-09

申请人： Genentech, Inc.

发明人： Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

IPC分类号： C07D471/02 ,  C07D487/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  C07D487/04

摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

公开(公告)号：US20220389020A1

公开(公告)日：2022-12-08

申请号：US17648045

申请日：2022-01-14

申请人： Genentech, Inc.

发明人： Paul Gibbons ,  Emily Hanan ,  Wendy Liu ,  Joseph P. Lyssikatos ,  Steven R. Magnuson ,  Rohan Mendonca ,  Richard Pastor ,  Thomas E. Rawson ,  Michael Siu ,  Mark E. Zak ,  Aihe Zhou ,  Bing-Yan Zhu ,  Christopher Hurley

IPC分类号： C07D487/04 ,  A61P17/06 ,  A61P35/02 ,  A61K31/519 ,  A61P29/00

摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

公开(公告)号：US20190263794A1

公开(公告)日：2019-08-29

申请号：US16398795

申请日：2019-04-30

申请人： Genentech, Inc.

发明人： Sarah M. Bronner ,  James J. Crawford ,  Andrew Cridland ,  Patrick Cyr ,  Benjamin Fauber ,  Emanuela Gancia ,  Alberto Gobbi ,  Christopher Hurley ,  Jonathan Killen ,  Wendy Lee ,  Olivier Rene ,  Monique Bodil Van Niel ,  Stuart Ward ,  Paul Winship ,  Jason Zbieg

IPC分类号： C07D413/14 ,  C07D403/14 ,  C07D405/14

摘要： Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US10280144B2

公开(公告)日：2019-05-07

申请号：US15801192

申请日：2017-11-01

申请人： Genentech, Inc.

发明人： Benjamin Fauber ,  James J. Crawford ,  Sarah M. Bronner ,  Monique Bodil van Niel ,  Andrew Cridland ,  Emanuela Gancia ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC分类号： C07D237/26 ,  C07D237/28

摘要： Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US09981916B2

公开(公告)日：2018-05-29

申请号：US14533358

申请日：2014-11-05

申请人： Genentech, Inc.

发明人： Monique Bodil van Niel ,  Andrew Cridland ,  Benjamin Fauber ,  Alberto Gobbi ,  Christopher Hurley ,  David Hurst ,  Jonathan Killen ,  Robert Maxey ,  Stuart Ward

IPC分类号： C07D237/28 ,  C07D403/06 ,  C07D413/06 ,  C07D401/04 ,  C07D417/04 ,  C07D405/12 ,  C07D491/048 ,  C07D403/14 ,  C07D491/107 ,  C07D401/12

CPC分类号： C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D491/048 ,  C07D491/107

摘要： Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US10131644B2

公开(公告)日：2018-11-20

申请号：US15199447

申请日：2016-06-30

申请人： Genentech, Inc.

发明人： Monique Bodil van Niel ,  Benjamin Fauber ,  Emanuela Gancia ,  Simon Gaines ,  Alberto Gobbi ,  Christopher Hurley ,  Tammy Ladduwahetty ,  Olivier Rene ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC分类号： C07D279/02 ,  C07D417/10 ,  C07D417/12

摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

公开(公告)号：US09994551B2

公开(公告)日：2018-06-12

申请号：US15801178

申请日：2017-11-01

申请人： Genentech, Inc.

发明人： Benjamin Fauber ,  Monique Bodil van Niel ,  Andrew Cridland ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward ,  Paul Winship

IPC分类号： C07D403/12 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D403/12 ,  C07D237/26 ,  C07D237/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： Compounds of formula I: or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20180072683A1

公开(公告)日：2018-03-15

申请号：US15801192

申请日：2017-11-01

申请人： Genentech, Inc.

发明人： Benjamin Fauber ,  James J. Crawford ,  Sarah M. Bronner ,  Monique Bodil van Niel ,  Andrew Cridland ,  Emanuela Gancia ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC分类号： C07D237/26

CPC分类号： C07D237/26 ,  C07D237/28

摘要： Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.