发明授权
- 专利标题: Dual receptor antagonistic antigen-binding proteins and uses thereof
- 专利标题(中): 双重受体拮抗抗原结合蛋白及其用途
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申请号: US14407421申请日: 2013-06-11
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公开(公告)号: US09453080B2公开(公告)日: 2016-09-27
- 发明人: Huiquan Han , Xiaolan Zhou , Qing Chen , Mei-Mei Tsai
- 申请人: Amgen Inc.
- 申请人地址: US CA Thousand Oaks
- 专利权人: AMGEN INC.
- 当前专利权人: AMGEN INC.
- 当前专利权人地址: US CA Thousand Oaks
- 代理机构: Fenwick & West LLP
- 国际申请: PCT/US2013/045245 WO 20130611
- 国际公布: WO2013/188448 WO 20131219
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C12N15/13 ; C12P21/08 ; A61K39/395 ; C07K16/46 ; A61K39/00
摘要:
This disclosure relates to antagonistic dual receptor antigen-binding proteins, e.g. antibodies and methods of using the dual receptor antibodies for treatment of pathological diseases. The dual receptor antibodies may comprise an antibody to ActRII receptors and may be used to treat pathological condition. The pathological conditions can comprise muscle wasting diseases or any disease that requires stimulation of muscle growth.
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