Invention Grant
US09457030B2 Compositions and methods for the treatment of juvenile neuronal ceroid lipofuscinosis and related disorders
有权
用于治疗青少年神经元类脂质脂褐质激素和相关疾病的组合物和方法
- Patent Title: Compositions and methods for the treatment of juvenile neuronal ceroid lipofuscinosis and related disorders
- Patent Title (中): 用于治疗青少年神经元类脂质脂褐质激素和相关疾病的组合物和方法
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Application No.: US14066506Application Date: 2013-10-29
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Publication No.: US09457030B2Publication Date: 2016-10-04
- Inventor: Tammy Kielian
- Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- Applicant Address: US NE Lincoln
- Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- Current Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- Current Assignee Address: US NE Lincoln
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K31/522
- IPC: A61K31/522 ; A61K31/4545 ; A61K31/4015 ; A61K31/44 ; A61K31/4425 ; A61K45/06 ; A61K38/17
Abstract:
Provided are materials and methods for the prevention and treatment of Juvenile Neuronal Ceroid Lipofuscinosis comprising administration of an effective amount of at least one of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor. In some embodiments, the methods comprise administration of an effective amount of each of a hemi-channel inhibitor and a phosphodiesterase-4 inhibitor. Also provided are pharmaceutical compositions comprising a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor, as well as kits comprising at least one effective dose of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor or a combination of both.
Public/Granted literature
Information query
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