公开(公告)号：US20210315816A1

公开(公告)日：2021-10-14

申请号：US17261074

申请日：2019-09-12

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Tammy Kielian ,  Tatiana Bronich ,  Kelsey Yamada ,  Xinyuan Xi

IPC: A61K9/107 ,  A61K31/365 ,  A61K47/66 ,  A61K45/06 ,  A61P31/04

Abstract: The present invention provides compositions and methods for the inhibition of a bacterial infection. More specifically, the present invention relates to compositions and methods for the inhibition and/or treatment of a bacterial infection, particularly an infection characterized by a biofilm. In a particular embodiment, the micelle comprises at least one block copolymer comprising an ionically charged polymeric segment and a non-ionically charged polymeric segment, wherein the ionically charged polymeric segment is grafted with hydrophobic moieties

公开(公告)号：US20170049761A1

公开(公告)日：2017-02-23

申请号：US15251855

申请日：2016-08-30

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Tammy Kielian

IPC: A61K31/4425 ,  A61K38/17 ,  A61K31/4545 ,  A61K31/522 ,  A61K31/4015 ,  A61K31/44

CPC classification number: A61K31/4425 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/522 ,  A61K38/17 ,  A61K38/177 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided are materials and methods for the prevention and treatment of Juvenile Neuronal Ceroid Lipofuscinosis comprising administration of an effective amount of at least one of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor. In some embodiments, the methods comprise administration of an effective amount of each of a hemi-channel inhibitor and a phosphodiesterase-4 inhibitor. Also provided are pharmaceutical compositions comprising a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor, as well as kits comprising at least one effective dose of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor or a combination of both.

Abstract translation: 提供了用于预防和治疗少年神经元细胞脂褐色素沉积的材料和方法，包括施用有效量的半通道抑制剂或磷酸二酯酶-4抑制剂中的至少一种。 在一些实施方案中，所述方法包括施用有效量的每种半通道抑制剂和磷酸二酯酶-4抑制剂。 还提供了包含半通道抑制剂或磷酸二酯酶-4抑制剂的药物组合物，以及包含至少一种有效剂量的半通道抑制剂或磷酸二酯酶-4抑制剂或两者的组合的试剂盒。

公开(公告)号：US09457030B2

公开(公告)日：2016-10-04

申请号：US14066506

申请日：2013-10-29

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Tammy Kielian

IPC: A61K31/522 ,  A61K31/4545 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/4425 ,  A61K45/06 ,  A61K38/17

CPC classification number: A61K31/4425 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/522 ,  A61K38/17 ,  A61K38/177 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided are materials and methods for the prevention and treatment of Juvenile Neuronal Ceroid Lipofuscinosis comprising administration of an effective amount of at least one of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor. In some embodiments, the methods comprise administration of an effective amount of each of a hemi-channel inhibitor and a phosphodiesterase-4 inhibitor. Also provided are pharmaceutical compositions comprising a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor, as well as kits comprising at least one effective dose of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor or a combination of both.

Abstract translation: 提供了用于预防和治疗少年神经元细胞脂褐色素沉积的材料和方法，包括施用有效量的半通道抑制剂或磷酸二酯酶-4抑制剂中的至少一种。 在一些实施方案中，所述方法包括施用有效量的每种半通道抑制剂和磷酸二酯酶-4抑制剂。 还提供了包含半通道抑制剂或磷酸二酯酶-4抑制剂的药物组合物，以及包含至少一种有效剂量的半通道抑制剂或磷酸二酯酶-4抑制剂或两者的组合的试剂盒。

公开(公告)号：US20220133896A1

公开(公告)日：2022-05-05

申请号：US17431049

申请日：2020-03-06

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Bin Duan ,  Mitchell Kuss ,  Tammy Kielian ,  Amy Aldrich ,  Wen Shi

IPC: A61K47/61 ,  B33Y80/00 ,  B33Y70/10 ,  A61L27/52 ,  A61L27/54 ,  A61K31/496 ,  A61K38/12 ,  A61K47/69

Abstract: Three-dimensional printed antibiotic scaffolds are provided as well as methods of use thereof and methods of making.

公开(公告)号：US10363282B2

公开(公告)日：2019-07-30

申请号：US15869396

申请日：2018-01-12

Applicant: Board of Regents of The University of Nebraska ,  San Diego State University Research Foundation

Inventor： Sam D. Sanderson ,  Joy Arlene Phillips ,  Edward Leroy Morgan ,  Marilyn Louise Thoman ,  Tamsin Sheen ,  Kelly S. Doran ,  Elizabeth Louise Virts ,  Tammy Kielian ,  Mark Hanke

IPC: A61K38/08 ,  A61K38/10 ,  A61K45/06

Abstract: Materials and methods for treating an infection or disease, activating an immune cell at a site of infection or disease, and for directly killing microorganisms, using response-selective carboxy-terminal C5a analogs, are provided.

公开(公告)号：US20190032078A1

公开(公告)日：2019-01-31

申请号：US15537384

申请日：2015-12-16

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  OHIO STATE INNOVATION FOUNDATION

Inventor： Tammy Kielian ,  Kevin Foust

IPC: C12N15/86 ,  A61P25/00

Abstract: Compositions and methods for the treatment of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Juvenile Batten Disease, are provided herein. In certain embodiments the compositions include but are not limited to adeno-associated viral (AAV) constructs, including self-complementary adeno-associated viral (sc-AAV) constructs, that express the human gene CLN3 (or a CLN3 cDNA).

公开(公告)号：US20180140659A1

公开(公告)日：2018-05-24

申请号：US15869396

申请日：2018-01-12

Applicant: Board of Regents of The University of Nebraska ,  San Diego State University Research Foundation

Inventor： Sam D. Sanderson ,  Joy Arlene Phillips ,  Edward Leroy Morgan ,  Marilyn Louise Thoman ,  Tamsin Sheen ,  Kelly S. Doran ,  Elizabeth Louise Virts ,  Tammy Kielian ,  Mark Hanke

IPC: A61K38/08 ,  A61K45/06 ,  A61K38/10

CPC classification number: A61K38/08 ,  A61K38/10 ,  A61K45/06 ,  Y02A50/463 ,  Y02A50/473

Abstract: Materials and methods for treating an infection or disease, activating an immune cell at a site of infection or disease, and for directly killing microorganisms, using response-selective carboxy-terminal C5a analogs, are provided.

公开(公告)号：US12297447B2

公开(公告)日：2025-05-13

申请号：US17131564

申请日：2020-12-22

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  OHIO STATE INNOVATION FOUNDATION

Inventor： Tammy Kielian ,  Kevin Foust

IPC: A01N63/00 ,  A61K48/00 ,  A61P25/00 ,  C12N15/86 ,  C12N15/864

Abstract: Compositions and methods for the treatment of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Juvenile Batten Disease, are provided herein. In certain embodiments the compositions include but are not limited to adeno-associated viral (AAV) constructs, including self-complementary adeno-associated viral (sc-AAV) constructs, that express the human gene CLN3 (or a CLN3 cDNA).

公开(公告)号：US10821178B2

公开(公告)日：2020-11-03

申请号：US14908028

申请日：2014-07-29

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Tammy Kielian

IPC: A61K39/395 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  C12N5/0786 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  G01N33/50

Abstract: Compositions and methods for preventing, ameliorating or treating biofilm infections are provided, including biofilms comprising at least one Pseudomonad or Staphylococcus, such as S. aureus. The biofilm infections may be associated with artificial joints, prostheses or implants.

公开(公告)号：US20160158353A1

公开(公告)日：2016-06-09

申请号：US14908028

申请日：2014-07-29

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Tammy Kielian

IPC: A61K39/395 ,  A61K38/21 ,  A61K38/19 ,  A61K38/18 ,  C07K16/18 ,  C07K16/28 ,  A61K45/06 ,  G01N33/50 ,  A61K38/20

CPC classification number: A61K39/3955 ,  A61K38/1841 ,  A61K38/191 ,  A61K38/2066 ,  A61K38/217 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  C12N5/0645 ,  C12N2501/231 ,  G01N33/5091 ,  G01N2333/46 ,  G01N2800/26

Abstract: Compositions and methods for preventing, ameliorating or treating biofilm infections are provided, including biofilms comprising at least one Pseudomonad or Staphylococcus, such as S. aureus. The biofilm infections may be associated with artificial joints, prostheses or implants.

Abstract translation: 提供了用于预防，改善或治疗生物膜感染的组合物和方法，包括包含至少一种假单胞菌属或葡萄球菌（例如金黄色葡萄球菌）的生物膜。 生物膜感染可能与人造关节，假体或植入物有关。