Invention Grant
US09458076B2 Using mixtures of E/Z isomers to obtain quantitatively specific products by combined asymmetric hydrogenations
有权
使用E / Z异构体的混合物通过组合的不对称氢化获得定量的特异性产物
- Patent Title: Using mixtures of E/Z isomers to obtain quantitatively specific products by combined asymmetric hydrogenations
- Patent Title (中): 使用E / Z异构体的混合物通过组合的不对称氢化获得定量的特异性产物
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Application No.: US14652339Application Date: 2013-12-18
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Publication No.: US09458076B2Publication Date: 2016-10-04
- Inventor: Werner Bonrath , Thomas Netscher , Jonathan Alan Medlock , René Tobias Stemmler , Gerardus Karel Maria Verzijl , Andreas Hendrikus Maria De Vries
- Applicant: DSM IP ASSETS B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agency: Nixon & Vanderhye P.C.
- Priority: EP12197850 20121218
- International Application: PCT/EP2013/077245 WO 20131218
- International Announcement: WO2014/096106 WO 20140626
- Main IPC: C07C45/62
- IPC: C07C45/62 ; C07C43/303 ; C07D311/58 ; C07C50/14 ; C07C45/82
Abstract:
The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
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