Invention Grant
- Patent Title: Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
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Application No.: US13730612Application Date: 2012-12-28
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Publication No.: US09458480B2Publication Date: 2016-10-04
- Inventor: Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
- Applicant: GENOMATICA, INC.
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C08G69/10
- IPC: C08G69/10 ; C12P17/12 ; C12P13/00 ; C12N1/00 ; C12N1/20 ; C08G69/26 ; C08G73/00 ; C07C205/00 ; C07C211/00 ; C12N1/38 ; C12N15/52 ; C12P7/40 ; C12P7/44 ; C12P13/02 ; C12P17/10
Abstract:
The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
Public/Granted literature
- US20130303723A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID Public/Granted day:2013-11-14
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