发明授权
US09464035B2 Salicylic acid derivatives useful as glucocerebrosidase activators
有权
可用作葡萄糖脑苷脂酶活化剂的水杨酸衍生物
- 专利标题： Salicylic acid derivatives useful as glucocerebrosidase activators
- 专利标题（中）： 可用作葡萄糖脑苷脂酶活化剂的水杨酸衍生物
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申请号： US14388494申请日： 2013-03-15
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公开(公告)号： US09464035B2公开(公告)日： 2016-10-11
- 发明人: Juan Jose Marugan , Wei Zheng , Samarjit Patnaik , Noel Southall , Ellen Sidransky , Ehud Goldin , Wendy Westbroek , Elma Aflaki , Steven Andrew Rogers , Frank John Schoenen
- 申请人： The United States of America, as Represented by the Secretary, Department of Health and Human Services , The University of Kansas
- 申请人地址： US DC Washington US KS Lawrence
- 专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE UNIVERSITY OF KANSAS
- 当前专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE UNIVERSITY OF KANSAS
- 当前专利权人地址： US DC Washington US KS Lawrence
- 代理机构： Cantor Colburn LLP
- 国际申请： PCT/US2013/032253 WO 20130315
- 国际公布： WO2013/148333 WO 20131003
- 主分类号： C07C235/64
- IPC分类号： C07C235/64 ; C07C235/60 ; C07C237/22
摘要：
Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R1-R13, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.
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