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发明授权
US09464044B2 Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient 有权
具有抑制11Beta-HSD1酶或其药学上可接受的盐的能力的化合物，其制备方法和含有作为活性成分的药物组合物

Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient
摘要：
The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof inhibiting 11β-HSD1 enzyme activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. Since the compound of the present invention selectively inhibits the activity of 11β-HSD1 (11β-Hydroxysteroid dehydrogenase type 1), the compound of the invention can be effectively used as a therapeutic agent for the treatment of diseases caused by the over-activation of 11β-HSD1 such as non-insulin dependent type II diabetes, insulin resistance, obesity, lipid disorder, metabolic syndrome, and other diseases or condition mediated by the excessive activity of glucocorticoid.
摘要（中）：

本发明涉及抑制11β-HSD1酶活性的新型化合物或其药学上可接受的盐，其制备方法以及含有该活性成分的药物组合物。 由于本发明化合物选择性地抑制11β-HSD1（11β-羟基类固醇脱氢酶1型）的活性，本发明化合物可有效地用作治疗由11β过度活化引起的疾病的治疗剂 -HSD1如非胰岛素依赖型II型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征等疾病或由糖皮质激素过度活性介导的病症。

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