Invention Grant
- Patent Title: Compositions and methods for amelioration and prevention of drug-induced toxicity
- Patent Title (中): 用于改善和预防药物毒性的组合物和方法
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Application No.: US14551724Application Date: 2014-11-24
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Publication No.: US09474763B2Publication Date: 2016-10-25
- Inventor: Josef Mograbi , Yaron Ilan
- Applicant: Hadasit Medical Research Services and Development Ltd. , Josef Mograbi
- Applicant Address: IL Jerusalem
- Assignee: Hadasit Medical Research Services and Development Ltd.
- Current Assignee: Hadasit Medical Research Services and Development Ltd.
- Current Assignee Address: IL Jerusalem
- Agency: Vorys, Sater, Seymour and Pease LLP
- Main IPC: A61K31/357
- IPC: A61K31/357 ; C07D309/36 ; A61K31/661 ; A61K45/06 ; A61K31/10 ; A61K31/167 ; A61K31/198 ; A61K31/685 ; A61K31/7056 ; A61K31/7076 ; A61K31/197
Abstract:
Pharmaceutical compositions including combinations of protective agents selected from isosilybin B, methylsulfonylmethane (MSM), phosphatidylcholine, cysteine (Cys), seleno-cysteine (Se-Cys), ribose-cysteine (RibCys), N-acetylcysteine (NAC), N-acetylcysteine-amide (AD4), methionine (Met) and S-adenosylmethionine (SAM) for reducing and/or preventing drug-induced toxicity, such as acetaminophen-induced toxicity. The compositions may be formulated with or without acetaminophen, and accordingly may be used as safe formulations of acetaminophen with reduced risk of causing liver damage, or as an antidote for the treatment of acetaminophen overdose. Methods for treating acetaminophen intoxication.
Public/Granted literature
- US20150080348A1 Compositions And Methods For Amelioration And Prevention Of Drug-Induced Toxicity Public/Granted day:2015-03-19
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