Invention Grant
US09476024B2 Thermoresponsive substrate with microgels, method for its preparation and culture method for biological cells
有权
具有微凝胶的热反应底物，其制备方法和生物细胞的培养方法
- Patent Title: Thermoresponsive substrate with microgels, method for its preparation and culture method for biological cells
- Patent Title (中): 具有微凝胶的热反应底物，其制备方法和生物细胞的培养方法
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Application No.: US13634577Application Date: 2011-03-21
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Publication No.: US09476024B2Publication Date: 2016-10-25
- Inventor: Claus Duschl , Andreas Lankenau , Stephan Schmidt , Thomas Hellweg , Erik Wischerhoff , Andre Laschewsky , Jean-Francois Lutz
- Applicant: Claus Duschl , Andreas Lankenau , Stephan Schmidt , Thomas Hellweg , Erik Wischerhoff , Andre Laschewsky , Jean-Francois Lutz
- Applicant Address: DE Munich
- Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
- Current Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
- Current Assignee Address: DE Munich
- Agency: Caesar Rivise, PC
- Priority: DE102010012252 20100322
- International Application: PCT/EP2011/001394 WO 20110321
- International Announcement: WO2011/116922 WO 20110929
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N5/00 ; C12M1/00 ; C12M1/12
Abstract:
The invention relates to a culture substrate having thermoresponsive microgel particles that have a thermoresponsive polymer and modulator particles fixed to the carrier area of the substrate. The modulator can be a substance that has an adhesion capability with biological cells or a substance that causes cellular reactions that are inducible to binding to surface receptors of biological cells. Methods for preparation and use in culturing cells are given.
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