A method of manufacturing a display panel is provided. The method includes preparing a mother panel, disposing a wheel unit on the mother panel, and cutting the mother panel along a plurality of cutting lines using the wheel unit. The mother panel includes a boundary of the mother panel and a plurality of unit panels within the boundary. Each of the plurality of unit panels includes a first substrate, a second substrate facing the first substrate, a display area, and a sealant. The sealant is disposed between the first and second substrates to couple the first and second substrates. The wheel unit applies different pressures to the first and second substrates to cut the first and second substrates when the mother panel is cut.