Various methods and devices that involve single transistor diode connected anti-fuse memory cells are disclosed. An exemplary memory cell comprises a thin gate insulator. The memory cell also comprises a bulk region of a first conductivity type in contact with a first side of the thin gate insulator. The memory cell also comprises a polysilicon gate electrode of the first conductivity type in contact with a second side of the thin gate insulator. The memory cell also comprises a source region of a second conductivity type in contact with the bulk region at a junction. The polysilicon gate electrode and the source region are operatively coupled to a programming voltage source that addresses the memory cell by blowing the thin gate insulator. The junction forms a diode for the memory cell. The bulk region can be in an active layer of a semiconductor on insulator structure.