发明授权
US09505729B2 Isoxazole analogs as mediators of transcriptional induction of E-cadherin
有权
异恶唑类似物作为E-钙粘蛋白转录诱导的介质
- 专利标题： Isoxazole analogs as mediators of transcriptional induction of E-cadherin
- 专利标题（中）： 异恶唑类似物作为E-钙粘蛋白转录诱导的介质
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申请号： US14828286申请日： 2015-08-17
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公开(公告)号： US09505729B2公开(公告)日： 2016-11-29
- 发明人: Craig W. Lindsley , Alex G. Waterson , R. Daniel Beauchamp
- 申请人： Vanderbilt University
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 代理机构： Ballard Spahr LLP
- 主分类号： C07D261/18
- IPC分类号： C07D261/18 ; C07D413/14 ; A61K31/42 ; C07D413/12 ; C07D403/12 ; C07D471/04 ; C07D231/14 ; C07D401/12
摘要：
In one aspect, the invention relates to N-((arylamino)alkyl)-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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