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公开(公告)号：US11318137B2
公开(公告)日：2022-05-03
申请号：US16500369
申请日：2017-05-17
发明人： Alex G. Waterson , Jason R. Abbott , J. Phillip Kennedy , Stephen W. Fesik , Qi Sun , Jason Phan , Michael C. Burns , Pratiq Patel
IPC分类号： C07D239/95 , A61K31/517 , A61K31/5377 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
摘要： The present invention relates to quinazoline compounds and compositions that modulate Ras signaling. Compounds and compositions of the present invention are useful in the treatment of cancers and other disease states associated with Ras dysfunction (e.g., Ras-associated autoimmune leukoproliferative disorder, or certain types of mitochondrial dysfunction) in a subject, for example a mammal or a human.
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公开(公告)号：US10813355B2
公开(公告)日：2020-10-27
申请号：US16186106
申请日：2018-11-09
发明人： Laurence Zwiebel , Gregory M. Pask , David C. Rinker , Ian M. Romaine , Gary A. Sulikowski , Paul R. Reid , Alex G. Waterson , Kwangho Kim , Patrick L. Jones , Robert W. Taylor
IPC分类号： A01N43/653 , A01N43/82 , A01N43/78 , A01N43/90 , A01N25/08 , A01N47/16 , A01N47/18 , A01N53/00 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D513/04
摘要： In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Methods of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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3.发明申请ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN 有权作为E-CADHERIN的转录诱导剂的异丙嗪类似物公开(公告)号：US20160052896A1
公开(公告)日：2016-02-25
申请号：US14828286
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D403/12 , C07D401/12 , C07D471/04 , C07D231/14 , C07D413/12 , C07D413/14
CPC分类号： C07D261/18 , C07D231/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04
摘要： In one aspect, the invention relates to N-((arylamino)alkyl)-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作E-钙粘蛋白转录诱导的介质的N - （（芳基氨基）烷基）-5-芳基异恶唑-3-甲酰胺类似物及其衍生物及其相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与E-钙粘蛋白活性相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US20160052895A1
公开(公告)日：2016-02-25
申请号：US14828230
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D417/12 , C07D401/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07D413/12 , C07D495/04
CPC分类号： C07D261/18 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： In one aspect, the invention relates to N-acetamidoalkyl-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及N-乙酰氨基烷基-5-芳基异恶唑-3-甲酰胺类似物，其衍生物和相关化合物，其可用作E-钙粘蛋白的转录诱导的介质; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与E-钙粘蛋白活性相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US20210219551A1
公开(公告)日：2021-07-22
申请号：US16945369
申请日：2020-07-31
发明人： Laurence Zwiebel , Gregory M. Pask , David C. Rinker , Ian M. Romaine , Gary A. Sulikowski , Paul R. Reid , Alex G. Waterson , Kwangho Kim , Patrick L. Jones , Robert W. Taylor
IPC分类号： A01N43/653 , A01N43/82 , A01N43/78 , A01N43/90 , A01N25/08 , A01N47/16 , A01N47/18 , A01N53/00 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D513/04
摘要： In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Methods of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10188105B2
公开(公告)日：2019-01-29
申请号：US15443340
申请日：2017-02-27
发明人： Laurence Zwiebel , Gregory M. Pask , David C. Rinker , Ian M. Romaine , Gary A. Sulikowski , Paul R. Reid , Alex G. Waterson , Kwangho Kim , Patrick L. Jones , Robert W. Taylor
IPC分类号： A01N43/653 , A01N43/78 , A01N43/90 , A01N43/82 , A01N53/00 , A01N47/16 , A01N47/18 , C07D491/052 , C07D401/14 , C07D409/14 , C07D405/14 , C07D513/04 , A01N25/08 , C07D249/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/14 , C07D471/04 , C07D491/048 , C07D491/056
摘要： In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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7.发明授权公开(公告)号：US09505729B2
公开(公告)日：2016-11-29
申请号：US14828286
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D413/14 , A61K31/42 , C07D413/12 , C07D403/12 , C07D471/04 , C07D231/14 , C07D401/12
CPC分类号： C07D261/18 , C07D231/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04
摘要： In one aspect, the invention relates to N-((arylamino)alkyl)-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作E-钙粘蛋白转录诱导的介质的N - （（芳基氨基）烷基）-5-芳基异恶唑-3-甲酰胺类似物及其衍生物及其相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与E-钙粘蛋白活性相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US20220289673A1
公开(公告)日：2022-09-15
申请号：US17631114
申请日：2020-07-29
发明人： William P. Tansey , Stephen W. Fesik , Shaun R. Stauffer , Alex G. Waterson , Changho Han , Joseph R. Alvarado , Jonathan D. MacDonald , Selena Chacon Simon , Sameer S. Nikhar , Alexey Kuznetsov
IPC分类号： C07C311/21 , C07C311/29 , C07C311/39 , C07C311/43 , C07C317/34 , C07C317/38 , C07C317/48 , C07C323/49 , C07C381/00 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/48 , C07D207/27 , C07D213/40 , C07D213/56 , C07D213/64 , C07D215/36 , C07D233/36 , C07D239/26 , C07D249/14 , C07D265/30 , C07D241/04 , C07D305/08 , C07D307/14 , C07D307/18 , C07D307/22 , C07D307/52 , C07D307/79 , C07D309/04 , C07D309/10 , C07D309/14 , C07D309/22 , C07D333/20 , C07D333/24
摘要： Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
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公开(公告)号：US20190075798A1
公开(公告)日：2019-03-14
申请号：US16186106
申请日：2018-11-09
发明人： Laurence Zwiebel , Gregory M. Pask , David C. Rinker , Ian M. Romaine , Gary A. Sulikowski , Paul R. Reid , Alex G. Waterson , Kwangho Kim , Patrick L. Jones , Robert W. Taylor
IPC分类号： A01N43/653 , C07D491/048 , C07D491/056 , A01N25/08 , A01N47/16 , A01N47/18 , A01N53/00 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D513/04 , C07D491/052 , A01N43/82 , A01N43/90 , A01N43/78 , A01N25/34 , A01N27/00 , A01N29/02 , A01N33/18 , A01N33/22 , A01N47/08 , A01N47/14 , A01N57/12 , A01N57/14 , A01N57/16
摘要： In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Methods of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US09783510B2
公开(公告)日：2017-10-10
申请号：US14828230
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D413/14
CPC分类号： C07D261/18 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： In one aspect, the invention relates to N-acetamidoalkyl-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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