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1.发明授权公开(公告)号：US09505729B2
公开(公告)日：2016-11-29
申请号：US14828286
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D413/14 , A61K31/42 , C07D413/12 , C07D403/12 , C07D471/04 , C07D231/14 , C07D401/12
CPC分类号： C07D261/18 , C07D231/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04
摘要： In one aspect, the invention relates to N-((arylamino)alkyl)-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作E-钙粘蛋白转录诱导的介质的N - （（芳基氨基）烷基）-5-芳基异恶唑-3-甲酰胺类似物及其衍生物及其相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与E-钙粘蛋白活性相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US09783510B2
公开(公告)日：2017-10-10
申请号：US14828230
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D413/14
CPC分类号： C07D261/18 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： In one aspect, the invention relates to N-acetamidoalkyl-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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3.发明申请ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN 有权作为E-CADHERIN的转录诱导剂的异丙嗪类似物公开(公告)号：US20160052896A1
公开(公告)日：2016-02-25
申请号：US14828286
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D403/12 , C07D401/12 , C07D471/04 , C07D231/14 , C07D413/12 , C07D413/14
CPC分类号： C07D261/18 , C07D231/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04
摘要： In one aspect, the invention relates to N-((arylamino)alkyl)-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作E-钙粘蛋白转录诱导的介质的N - （（芳基氨基）烷基）-5-芳基异恶唑-3-甲酰胺类似物及其衍生物及其相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与E-钙粘蛋白活性相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US20160052895A1
公开(公告)日：2016-02-25
申请号：US14828230
申请日：2015-08-17
IPC分类号： C07D261/18 , C07D417/12 , C07D401/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07D413/12 , C07D495/04
CPC分类号： C07D261/18 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： In one aspect, the invention relates to N-acetamidoalkyl-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及N-乙酰氨基烷基-5-芳基异恶唑-3-甲酰胺类似物，其衍生物和相关化合物，其可用作E-钙粘蛋白的转录诱导的介质; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与E-钙粘蛋白活性相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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