Invention Grant
US09505779B2 Tacrolimus analogues, a neuroprotective composition comprising the same, an immunosuppressive composition comprising the same, a method for preparing the same, and a mutant for producing the same
有权
他克莫司类似物，包含该组合物的神经保护组合物，包含该组合物的免疫抑制组合物，其制备方法和用于制备该组合物的突变体
- Patent Title: Tacrolimus analogues, a neuroprotective composition comprising the same, an immunosuppressive composition comprising the same, a method for preparing the same, and a mutant for producing the same
- Patent Title (中): 他克莫司类似物，包含该组合物的神经保护组合物，包含该组合物的免疫抑制组合物，其制备方法和用于制备该组合物的突变体
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Application No.: US13774899Application Date: 2013-02-22
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Publication No.: US09505779B2Publication Date: 2016-11-29
- Inventor: Yeo Joon Yoon , Jae Jong Kim , Si Kyu Lim
- Applicant: EWHA University—Industry Collaboration Foundation
- Applicant Address: KR Seongnam-Si, Gyeonggi-Do
- Assignee: Intron Biotechnology, Inc.
- Current Assignee: Intron Biotechnology, Inc.
- Current Assignee Address: KR Seongnam-Si, Gyeonggi-Do
- Agency: McNees Wallace & Nurick LLC
- Priority: KR10-2010-0082059 20100824; KR10-2011-0032278 20110407
- Main IPC: C07D491/12
- IPC: C07D491/12 ; C12N9/10 ; A61K31/00 ; C07D493/16 ; C12P17/18 ; C07D498/18 ; C12N15/52
Abstract:
The present invention relates to novel tacrolimus analogs, a composition for the prevention or treatment of neurological diseases or immune hypersensitivity disorders comprising the same, a method for preventing or treating neurological diseases or immune hypersensitivity disorders comprising administering the analogs to a subject, a method for preparing the analogs using an isolated modified Streptomyces sp. strain wherein the activity of one or more enzymes selected from the group consisting of TcsA, TcsB, TcsC and TcsD is reduced; and the isolated modified Streptomyces sp. strain for prepare the analogs.
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