公开(公告)号：US09505779B2

公开(公告)日：2016-11-29

申请号：US13774899

申请日：2013-02-22

Applicant: EWHA University—Industry Collaboration Foundation

Inventor： Yeo Joon Yoon ,  Jae Jong Kim ,  Si Kyu Lim

IPC: C07D491/12 ,  C12N9/10 ,  A61K31/00 ,  C07D493/16 ,  C12P17/18 ,  C07D498/18 ,  C12N15/52

CPC classification number: C07D493/16 ,  C07D498/18 ,  C12N9/1029 ,  C12N15/52 ,  C12P17/188 ,  Y02P20/52

Abstract: The present invention relates to novel tacrolimus analogs, a composition for the prevention or treatment of neurological diseases or immune hypersensitivity disorders comprising the same, a method for preventing or treating neurological diseases or immune hypersensitivity disorders comprising administering the analogs to a subject, a method for preparing the analogs using an isolated modified Streptomyces sp. strain wherein the activity of one or more enzymes selected from the group consisting of TcsA, TcsB, TcsC and TcsD is reduced; and the isolated modified Streptomyces sp. strain for prepare the analogs.

Abstract translation: 本发明涉及新的他克莫司类似物，用于预防或治疗神经系统疾病的组合物或包含该组合物的免疫过敏性疾病，用于预防或治疗神经疾病或免疫超敏反应障碍的方法，包括给予受试者的类似物， 使用分离的修饰链霉菌sp。 其中选自TcsA，TcsB，TcsC和TcsD的一种或多种酶的活性降低; 和分离的修饰链霉菌属 应变来准备类似物。