The multiple shot spear gun includes a central rotary shaft having a plurality of relatively stationary spear launching tubes or barrels distributed therearound in a cylindrical pattern. The number of spear launching tubes or barrels is not limited, but may comprise any practicable number. Rotation of the central shaft causes a disc to rotate. The disc has a ramp or tang thereon that sequentially engages the trigger of each of the spear launchers as the disc is rotated. A safety disc is rotated with rotation of the central shaft. The safety disc includes a plurality of holes therein. A spring-loaded catch engages one of the holes as the disc rotates with rotation of the central shaft. Thus, the operator of the multiple shot spear gun must release the safety catch after each shot to rotate the central shaft further for the next shot.