发明授权
- 专利标题: Magnetic resonance imaging (MRI) with dual agent characterization
- 专利标题(中): 具有双重特征的磁共振成像(MRI)
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申请号: US14068537申请日: 2013-10-31
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公开(公告)号: US09508256B2公开(公告)日: 2016-11-29
- 发明人: Susann Brady-Kalnay , Vikas Gulani , Mark Griswold
- 申请人: Case Western Reserve University
- 申请人地址: US OH Cleveland
- 专利权人: CASE WESTERN RESERVE UNIVERSITY
- 当前专利权人: CASE WESTERN RESERVE UNIVERSITY
- 当前专利权人地址: US OH Cleveland
- 代理机构: Quarles & Brady LLP
- 主分类号: A61K49/06
- IPC分类号: A61K49/06 ; G01R33/48 ; G01R33/56 ; G01R33/563 ; G01R33/58 ; A61B5/055 ; G08C23/06 ; G01R33/36 ; A61B5/00
摘要:
Example apparatus and methods concern determining whether a target material appears in a region experiencing nuclear magnetic resonance. One method acquires a baseline value for a magnetic resonance parameter (MRP) while the region is not exposed to a molecular imaging agent that affects the MRP, acquiring a non-specific uptake value for the MRP while the sample is influenced by a non-specific molecular imaging agent and acquiring a specific uptake value for the MRP while the sample is influenced by a specific molecular imaging agent. The non-specific masking problem is solved by characterizing the region as a function of the baseline value, the non-specific uptake value, and the specific uptake value. The function relies on the similarities and differences between non-specific uptake of the non-specific molecular imaging agent, non-specific uptake of the specific molecular imaging agent, and specific uptake of the specific molecular imaging agent.