公开(公告)号：US12210019B2

公开(公告)日：2025-01-28

申请号：US17072076

申请日：2020-10-16

Applicant: Case Western Reserve University

Inventor： Aaron Weinberg ,  Santosh Ghosh ,  Umut A. Gurkan

IPC: G01N33/574 ,  G01N33/543

Abstract: A method of detecting epithelial cancer is described that includes the steps of: (a) determining the level of beta defensin 3 (BD-3) and beta defensin 2 (BD-2) in a suspect sample obtained from a subject; (b) comparing the level of BD-3 to BD-2 determined in the suspect sample to obtain a suspect BD-3/BD-2 ratio, (c) comparing the suspect BD-3/BD-2 ratio to a healthy BD-3/BD-2 ratio to obtain a diagnostic BD-3/BD-2 ratio; and (d) characterizing the subject as having epithelial cancer if the diagnostic BD-3/BD-2 ratio is greater than 1. A microfluidic device for detecting epithelial cancer using the diagnostic BD-3/BD-2 ratio is also described.

公开(公告)号：US12209568B2

公开(公告)日：2025-01-28

申请号：US18513520

申请日：2023-11-18

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Changyong Cao ,  Yuhui Fang

IPC: F03B13/20

Abstract: A triboelectric-electromagnetic hybrid nanogenerator (TEHG) includes a ball-based triboelectric nanogenerator (TENG) and an electromagnetic generator (EMG) configured to move due to exterior fluid movement to generate triboelectric and electromagnetic charging for harvesting wave energy.

公开(公告)号：US12203073B2

公开(公告)日：2025-01-21

申请号：US17129463

申请日：2020-12-21

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Nicole F. Steinmetz

IPC: C07H21/04 ,  A61K45/06 ,  A61K47/62 ,  A61K47/69 ,  C12N7/00 ,  C12N15/113

Abstract: A nanoparticle includes an icosahedral-shaped plant virus particle; an RNAi construct; and one or more endolysosomal release agents, wherein the RNAi construct is noncovalently loaded within the icosahedral-shaped plant virus particle.

公开(公告)号：US20250011636A1

公开(公告)日：2025-01-09

申请号：US18613999

申请日：2024-03-22

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Yusuf Dikici ,  Ozan Akkus

IPC: C09K3/00

Abstract: A hybrid metamaterial structure includes at least one auxetic portion and at least one non-auxetic portion connected to the auxetic portion. The at least one non-auxetic portion has a nodal honeycomb unit geometry.

公开(公告)号：US20250009706A1

公开(公告)日：2025-01-09

申请号：US18580474

申请日：2022-07-18

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Stephen J. Lewis

IPC: A61K31/223 ,  A61K31/225 ,  A61K31/485 ,  A61P25/36

Abstract: A method of treating opioid withdrawal and/or dependence in a subject in need thereof, includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine ester, a cystine ester, or an adduct, a pharmaceutically acceptable salt, a tautomer, or a solvate thereof.

公开(公告)号：US20250000847A1

公开(公告)日：2025-01-02

申请号：US18687441

申请日：2022-08-31

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Paul J. Tesar ,  Benjamin L.L. Clayton

IPC: A61K31/415 ,  A61K31/167 ,  A61K31/4192 ,  A61P25/00

Abstract: The invention described herein provides methods and reagents for treating diseases or conditions associated with reactive astrocytes using HD AC inhibitors, such as HDAC3-specific inhibitors.

公开(公告)号：US20240408092A1

公开(公告)日：2024-12-12

申请号：US18624553

申请日：2024-04-02

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Bingcheng Wang ,  Bin Su ,  Aaron Petty

IPC: A61K31/517 ,  A61K45/06 ,  C07D403/04

Abstract: A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a compound, the small molecule having a general formula: A-L-X—Z (I).

公开(公告)号：US12156884B2

公开(公告)日：2024-12-03

申请号：US17172150

申请日：2021-02-10

Applicant: Case Western Reserve University

Inventor： Mei Zhang ,  Alex Y. Huang ,  Julian Kim

IPC: A61K31/716 ,  A61P35/00

Abstract: A method of treating a subject having cancer is described that includes administering a therapeutically effective amount of a β-(1,3)-(1,4) glucan to the subject. Methods of immunostimulating in a subject by administering an effective amount of a β-(1,3)-(1,4) glucan to the subject are also described.

公开(公告)号：US12151047B2

公开(公告)日：2024-11-26

申请号：US16641056

申请日：2018-07-25

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Jung-Youn Shin ,  Robyn Marks ,  Mitchell Hopkins ,  Hongyun Park

IPC: A61L27/44 ,  A61L27/20 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08B37/00 ,  C08G65/00 ,  C08H1/06 ,  C08L5/04 ,  C08L89/06

Abstract: A composition includes a hydrogel that includes a plurality biodegradable natural polymer macromers crosslinked with a first agent and optionally a plurality of cells dispersed in the crosslinked macromers, the microgels are capable of being crosslinked with a second agent that is different than the first crosslinking agent.

公开(公告)号：US20240385268A1

公开(公告)日：2024-11-21

申请号：US18665093

申请日：2024-05-15

Applicant: Case Western Reserve University ,  Vanderbilt University

Inventor： Sai Abitha Srinivas ,  William A. Grissom ,  Mark A. Griswold

IPC: G01R33/483 ,  G01R33/3415 ,  G01R33/56 ,  G01R33/58

Abstract: A system for RF based frequency encoding utilizing a Bloch-Siegert shift, includes a controller, an RF encoding system, and an injection transformer simultaneous transmit and receive filter. The controller generates RF excitation pulses, RF based frequency encoding pulses, and a cancellation signal. The RF encoding system includes one or more RF coils configured to transmit the RF excitation pulses and RF based frequency encoding pulses, and to receive an MR signal from the subject where the MR signal includes a leakage signal induced by the RF based frequency encoding pulses. The injection transformer simultaneous transmit and receive filter is in signal communication with the controller and the RF encoding system. The injection transformer simultaneous transmit receive filter is configured to receive the cancellation signal, the MR signal including the leakage signal, and to cancel the leakage signal from the received MR signal to generate a filtered MR signal.