发明授权
US09517261B2 Second generation virus-like particles (VLP) from Epstein-Barr viruses for vaccination purposes
有权
来自爱泼斯坦 - 巴尔病毒的第二代病毒样颗粒（VLP）用于疫苗接种目的
- 专利标题： Second generation virus-like particles (VLP) from Epstein-Barr viruses for vaccination purposes
- 专利标题（中）： 来自爱泼斯坦 - 巴尔病毒的第二代病毒样颗粒（VLP）用于疫苗接种目的
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申请号： US14366645申请日： 2012-12-28
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公开(公告)号： US09517261B2公开(公告)日： 2016-12-13
- 发明人: Regina Feederle , Sophia Hundt , Henri-Jacques Delecluse
- 申请人： Deutsches Krebsforschungszentrum
- 申请人地址： DE Heidelberg
- 专利权人： DEUTSCHES KREBSFORSCHUNGSZENTRUM
- 当前专利权人： DEUTSCHES KREBSFORSCHUNGSZENTRUM
- 当前专利权人地址： DE Heidelberg
- 代理机构： Foley & Lardner LLP
- 优先权： EP11196215 20111230
- 国际申请： PCT/EP2012/077007 WO 20121228
- 国际公布： WO2013/098364 WO 20130704
- 主分类号： A61K39/245
- IPC分类号： A61K39/245 ; C12N15/86 ; C12N7/00 ; A61K39/00 ; A61K39/12 ; C07K14/005 ; C07K16/08
摘要：
The present invention relates to an Epstein-Barr virus-like particle (EB-VLP) substantially free of Epstein-Barr Virus (EBV) DNA. The present invention also relates to a polynucleotide comprising an EBV genome a) lacking at least one expressible gene selected from the group consisting of the BFLF1 gene, the BBRF gene, the BGRF1 gene, the BDRF1 gene, the BALF3 gene, the BFRF1A gene, and the BFRF1 gene, and b) producing the EB-VLP of the invention in a suitable host cell. The present invention further relates to a vector and a host cell comprising the polynucleotide of the invention as well to a method of manufacturing the EB-VLPs, a method of manufacturing a vaccine thereof, a vaccine and a composition comprising the EB-VLPs.
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