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    B-cell receptor complex binding proteins containing T-cell epitopes
    2.
    发明授权
    B-cell receptor complex binding proteins containing T-cell epitopes 有权

    公开(公告)号：US10961280B2

    公开(公告)日：2021-03-30

    申请号：US16030663

    申请日：2018-07-09

    申请人： Deutsches Krebsforschungszentrum

    发明人： Henri-Jacques Delecluse ,  Regina Feederle ,  Emmalene Bartlett

    IPC分类号： A61K39/12 ,  A61K39/245 ,  C07K14/005 ,  C07K16/28 ,  C12N7/00 ,  A61K39/00

    摘要： The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of CD22, CD19, CD20, and CD21, and b) an immunogenic peptide comprising at least one T-cell epitope for use in vaccination of a subject against B-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same. It also relates to a method for the stimulation of antigen-specific T-cells, comprising a) contacting antigen presenting cells (APC) with a polypeptide, the polynucleotide, or the vector of the invention, b) contacting said APC with T-cells, and c) thereby stimulating antigen-specific T-cells specific for said at least one T-cell epitope; to a method for immunizing a subject against B-cell hyperproliferation, to a method for immunizing a subject against an infectious agent, and to a method for inducing tolerance in a subject.

    IMPROVED EBV VACCINE
    4.
    发明申请
    IMPROVED EBV VACCINE 审中-公开

    公开(公告)号：US20190282691A1

    公开(公告)日：2019-09-19

    申请号：US16349153

    申请日：2017-11-10

    申请人： Deutsches Krebsforschungszentrum

    发明人： Henri-Jacques Delecluse ,  Anatoliy Shumilov ,  Ming-Han Tsai

    IPC分类号： A61K39/245 ,  C12N7/00 ,  A61P31/22

    摘要： The present invention relates to a composition comprising Epstein-Barr Virus (EBV) particles for use in vaccination of a subject, wherein said EBV particles comprise a significantly reduced chromosome instability-inducing EBV polypeptide activity. The present invention also relates to a composition comprising EBV particles for use in vaccination of a subject, wherein said vaccination comprises avoiding contacting the cytosol and/or nucleus of cells of said subject with a chromosome instability-inducing EBV polypeptide activity. Moreover, the present invention relates to polynucleotides, host cells, methods, and uses related to the aforesaid compositions.

    B-CELL RECEPTOR COMPLEX BINDING PROTEINS CONTAINING T-CELL EPITOPES
    6.
    发明申请
    B-CELL RECEPTOR COMPLEX BINDING PROTEINS CONTAINING T-CELL EPITOPES 审中-公开
    B细胞受体复合物包含T细胞外膜蛋白的蛋白质

    公开(公告)号：US20150050279A1

    公开(公告)日：2015-02-19

    申请号：US14386275

    申请日：2013-03-19

    申请人： Deutsches Krebsforschungszentrum

    发明人： Henri-Jacques Delecluse ,  Regina Feederle ,  Emmalene Bartlett

    IPC分类号： C07K14/005 ,  C07K16/28 ,  C12N7/00

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/55516 ,  A61K2039/572 ,  A61K2039/585 ,  A61K2039/6056 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2317/569 ,  C07K2319/33 ,  C12N7/00 ,  C12N2710/16222 ,  C12N2710/16234

    摘要： The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of CD22, CD19, CD20, and CD21, and b) an immunogenic peptide comprising at least one T-cell epitope for use in vaccination of a subject against B-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same. It also relates to a method for the stimulation of antigen-specific T-cells, comprising a) contacting antigen presenting cells (APC) with a polypeptide, the polynucleotide, or the vector of the invention, b) contacting said APC with T-cells, and c) thereby stimulating antigen-specific T-cells specific for said at least one T-cell epitope; to a method for immunizing a subject against B-cell hyperproliferation, to a method for immunizing a subject against an infectious agent, and to a method for inducing tolerance in a subject.

    摘要翻译： 本发明涉及包含a）与至少一种选自CD22，CD19，CD20和CD21的蛋白结合的结合肽，和b）包含至少一个T细胞表位的免疫原性肽用于 在对B细胞过度增生的受试者接种疫苗中或用于调节受试者的免疫应答。 本发明还涉及编码所述多肽的多核苷酸和载体以及包含该多肽的宿主细胞。 它还涉及刺激抗原特异性T细胞的方法，其包括a）使抗原呈递细胞（APC）与本发明的多肽，多核苷酸或载体接触，b）使所述APC与T细胞接触 和c）从而刺激对所述至少一种T细胞表位特异的抗原特异性T细胞; 涉及免疫B细胞过度增生的受试者的方法，针对感染性试剂免疫受试者的方法以及诱导受试者的耐受性的方法。

    EBV vaccine
    8.
    发明授权
    EBV vaccine 有权

    公开(公告)号：US11097003B2

    公开(公告)日：2021-08-24

    申请号：US16349153

    申请日：2017-11-10

    申请人： Deutsches Krebsforschungszentrum

    发明人： Henri-Jacques Delecluse ,  Anatoliy Shumilov ,  Ming-Han Tsai

    IPC分类号： A61K39/245 ,  A61P31/22 ,  C12N7/00 ,  A61K39/12

    摘要： The present invention relates to a composition comprising Epstein-Barr Virus (EBV) particles for use in vaccination of a subject, wherein said EBV particles comprise a significantly reduced chromosome instability-inducing EBV polypeptide activity. The present invention also relates to a composition comprising EBV particles for use in vaccination of a subject, wherein said vaccination comprises avoiding contacting the cytosol and/or nucleus of cells of said subject with a chromosome instability-inducing EBV polypeptide activity. Moreover, the present invention relates to polynucleotides, host cells, methods, and uses related to the aforesaid compositions.

    B-cell receptor complex binding proteins containing T-cell epitopes
    10.
    发明授权
    B-cell receptor complex binding proteins containing T-cell epitopes 有权

    公开(公告)号：US10040827B2

    公开(公告)日：2018-08-07

    申请号：US14386275

    申请日：2013-03-19

    申请人： Deutsches Krebsforschungszentrum

    发明人： Henri-Jacques Delecluse ,  Regina Feederle ,  Emmalene Bartlett

    IPC分类号： C07K14/05 ,  A61K39/245 ,  C07K14/005 ,  C07K16/28 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

    摘要： The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of CD22, CD19, CD20, and CD21, and b) an immunogenic peptide comprising at least one T-cell epitope for use in vaccination of a subject against B-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same. It also relates to a method for the stimulation of antigen-specific T-cells, comprising a) contacting antigen presenting cells (APC) with a polypeptide, the polynucleotide, or the vector of the invention, b) contacting said APC with T-cells, and c) thereby stimulating antigen-specific T-cells specific for said at least one T-cell epitope; to a method for immunizing a subject against B-cell hyperproliferation, to a method for immunizing a subject against an infectious agent, and to a method for inducing tolerance in a subject.