What is disclosed is a system and method for detecting febrile seizure using a thermal video camera. In one embodiment, a video is received comprising time-sequential thermal images of a subject. The video is acquired of the subject in real-time using a thermal video system. Each thermal image comprises a plurality of pixels with an intensity value of each pixel corresponding to a temperature. The thermal images are processed to determine an occurrence of a febrile seizure. The processing involves identifying a region of interest in the thermal image and determining a temperature for the region of interest based on values of the pixels isolated in that region of interest. Thereafter, a rate of change of temperatures is obtained for the subject in real-time on a per-frame basis. If the rate of change is determined to have exceeded a pre-defined threshold level, then the subject is having a febrile seizure.