发明授权
US09526801B2 Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
有权
异亚芳基桥连的苯并二氮杂二聚体，其共轭物，以及制备和使用方法
- 专利标题： Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
- 专利标题（中）： 异亚芳基桥连的苯并二氮杂二聚体，其共轭物，以及制备和使用方法
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申请号： US14994378申请日： 2016-01-13
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公开(公告)号： US09526801B2公开(公告)日： 2016-12-27
- 发明人: Ivar M. McDonald , Naidu S. Chowdari , Walter Lewis Johnson , Yong Zhang , Robert M. Borzilleri , Sanjeev Gangwar
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： US NJ Princeton
- 代理商 Yuan Chao
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D519/00 ; A61K47/48 ; C07K5/062
摘要：
Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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