Invention Grant
- Patent Title: Method for expanding hematopoietic stem cells using heterocyclic compound
- Patent Title (中): 使用杂环化合物扩增造血干细胞的方法
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Application No.: US12746666Application Date: 2008-12-06
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Publication No.: US09527828B2Publication Date: 2016-12-27
- Inventor: Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji , Shunsuke Iwamoto , Yasuyuki Asai , Makiko Yui
- Applicant: Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji , Shunsuke Iwamoto , Yasuyuki Asai , Makiko Yui
- Applicant Address: JP Tokyo JP Yokohama
- Assignee: Nissan Chemical Industries, Ltd.,ReproCELL Incorporated
- Current Assignee: Nissan Chemical Industries, Ltd.,ReproCELL Incorporated
- Current Assignee Address: JP Tokyo JP Yokohama
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2007-316276 20071206
- International Application: PCT/JP2008/072207 WO 20081206
- International Announcement: WO2009/072635 WO 20090611
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C07D333/38 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C12N5/0789 ; A61K35/00
Abstract:
An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided.A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
Public/Granted literature
- US20100266556A1 METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND Public/Granted day:2010-10-21
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