The present disclosure is directed to application integrity protection via secure interaction and processing. For example, interaction with a user interface in a device may result in input information being generated. Following encryption, the input information may be conveyed to an application executing in a secure processing environment. The encrypted input information may be received, decrypted and processed by the application. An example application may include a secure controller component, a secure model component and a secure view component. The secure controller component may, for example, provide change instructions to the secure model component based on the decrypted input information. The secure model component may then, if necessary, provide a change notification to the secure view component based on the change instructions. The secure view component may then generate output information, which may be encrypted prior to being provided to the user interface for decryption, processing and presentation.