A method using OTDOA for positioning a mobile station includes: transmitting to the mobile station an OTDOA capability request message to inquire about a communication system format supported by the mobile station and signal reception quality information of each base station of a communication system supported, where the OTDOA capability request message includes a plurality of communication formats existent in a current service area of the mobile station and corresponding signal reception quality information, provided for the mobile station to select based on the communication system format supported by the mobile station; receiving an OTDOA support capability message returned by the mobile station, where the OTDOA support capability message includes the communication system format supported by the mobile station and corresponding signal reception quality; sending to the mobile station auxiliary positioning information based on the communication system format supported by the mobile station and the corresponding signal reception quality.