Invention Grant
US09573872B2 Using mixtures of E/Z isomers to obtain quantitatively specific products by combining asymmetric hydrogenation and isomerization
有权
使用E / Z异构体的混合物通过组合不对称氢化和异构化来获得定量的特异性产物
- Patent Title: Using mixtures of E/Z isomers to obtain quantitatively specific products by combining asymmetric hydrogenation and isomerization
- Patent Title (中): 使用E / Z异构体的混合物通过组合不对称氢化和异构化来获得定量的特异性产物
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Application No.: US14652362Application Date: 2013-12-18
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Publication No.: US09573872B2Publication Date: 2017-02-21
- Inventor: Werner Bonrath , Thomas Netscher , Jonathan Alan Medlock , René Tobias Stemmler , Gerardus Karel Maria Verzijl , Andreas Hendrikus Maria De Vries
- Applicant: DSM IP ASSETS B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agency: Nixon & Vanderhye P.C.
- Priority: EP12197857 20121218
- International Application: PCT/EP2013/077246 WO 20131218
- International Announcement: WO2014/096107 WO 20140626
- Main IPC: C07C45/62
- IPC: C07C45/62 ; C07C45/67
Abstract:
The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves an asymmetric hydrogenation and an isomerization step. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
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