发明授权
- 专利标题： Methods of generating corneal cells and cell populations comprising same
- 专利标题（中）： 产生角膜细胞和包含其的细胞群的方法
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申请号： US13991172申请日： 2011-12-01
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公开(公告)号： US09574171B2公开(公告)日： 2017-02-21
- 发明人: Joseph Itskovitz-Eldor , Daniel Aberdam , Ruby Shalom-Feuerstein
- 申请人： Joseph Itskovitz-Eldor , Daniel Aberdam , Ruby Shalom-Feuerstein
- 申请人地址： IL Haifa FR Paris
- 专利权人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
- 当前专利权人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
- 当前专利权人地址： IL Haifa FR Paris
- 代理机构： Whitham, Curtis & Cook, P.C.
- 国际申请： PCT/IL2011/000914 WO 20111201
- 国际公布： WO2012/073238 WO 20120607
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12N5/02 ; C12N5/08 ; C07K1/00 ; G01N33/567 ; C12N5/079 ; G01N33/53
摘要：
A method of generating a population of corneal epithelial cells is disclosed. The method comprises culturing human pluripotent stem cells in corneal fibroblast-conditioned medium on a solid surface comprising an extracellular matrix component thereby generating the population of corneal epithelial cells. Isolated cell populations and corneal tissues are also disclosed, as well as uses thereof.
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