Invention Grant
US09574176B2 Neural stem cell having increased passage ability, method for manufacturing neural stem cell having said increased passage abiility, and method for culturing neural stem cells for increasing passage ability of neural stem cells
有权
具有增加的传代能力的神经干细胞，具有增加的通过能力的神经干细胞的制造方法和用于培养神经干细胞以增加神经干细胞通过能力的方法
- Patent Title: Neural stem cell having increased passage ability, method for manufacturing neural stem cell having said increased passage abiility, and method for culturing neural stem cells for increasing passage ability of neural stem cells
- Patent Title (中): 具有增加的传代能力的神经干细胞，具有增加的通过能力的神经干细胞的制造方法和用于培养神经干细胞以增加神经干细胞通过能力的方法
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Application No.: US14436206Application Date: 2013-10-29
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Publication No.: US09574176B2Publication Date: 2017-02-21
- Inventor: Norimasa Miyamoto , Yuichi Ono , Kana Namiki , Yoshitoshi Kasuya
- Applicant: Eisai R&D Management Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2012-241366 20121031
- International Application: PCT/JP2013/079200 WO 20131029
- International Announcement: WO2014/069431 WO 20140508
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N5/00 ; C12N5/08 ; C12N5/0797 ; C12N15/85
Abstract:
The present invention provides a neural stem cell having increased passage ability and a method for manufacturing a neural stem cell having increased passage ability. A neural stem cell in which the N-type calcium channel gene is knocked out or the influx of Ca2+ via the N-type calcium channel is substantially absent can be passaged for at least 4 generations and maintains the differentiation potential into a nerve cell even after passage for 4 generations.
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