Invention Grant
- Patent Title: Small molecule inhibitors of necroptosis
- Patent Title (中): 小分子抑制剂
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Application No.: US14033176Application Date: 2013-09-20
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Publication No.: US09586880B2Publication Date: 2017-03-07
- Inventor: Junying Yuan , Emily P. Hsu
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda H. Jarrell; Nishat A. Shaikh
- Main IPC: C07D233/02
- IPC: C07D233/02 ; C07C35/37 ; C07D209/08 ; C07D211/90 ; C07D215/08 ; C07D231/06 ; C07D231/12 ; C07D231/56 ; C07D277/46 ; C07D307/52 ; C07D333/20 ; C07D403/06 ; C07D403/12 ; C07D405/06 ; C07D417/12 ; C07D495/04 ; C07D498/08 ; C07C33/38 ; C07D211/78 ; C07D277/18
Abstract:
Compounds having the following structure (VI-A): or any pharmaceutically acceptable salt or solvate thereof, or any stereoisomer thereof, wherein RE1, RE2, RE3, RE4, ZE2 and ZE3 are as disclosed herein, are provided. Pharmaceutical compositions comprising the compounds, and methods for use of the compounds for treating disorders associated with necrosptosis are also provided.
Public/Granted literature
- US20140024657A1 SMALL MOLECULE INHIBITORS OF NECROPTOSIS Public/Granted day:2014-01-23
Information query
