Invention Grant
- Patent Title: Interleukin-13 binding proteins
- Patent Title (中): 白细胞介素-13结合蛋白
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Application No.: US14101145Application Date: 2013-12-09
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Publication No.: US09592293B2Publication Date: 2017-03-14
- Inventor: Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: Yankwich & Associates, P.C.
- Agent Mark J. Hyman, Esq.; Thomas R. Bierke, Esq.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K45/06 ; C07K14/47 ; C07K16/24 ; A61K38/00

Abstract:
The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
Public/Granted literature
- US20140099313A1 INTERLEUKIN-13 BINDING PROTEINS Public/Granted day:2014-04-10
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