公开(公告)号：US09447183B2

公开(公告)日：2016-09-20

申请号：US14107988

申请日：2013-12-16

Applicant: AbbVie, Inc.

Inventor： Chengbin Wu ,  Dominic J. Ambrosi ,  Chung-ming Hsieh ,  Tariq Ghayur

IPC: C12P21/08 ,  A61K38/00 ,  C07K14/545 ,  C07K16/24 ,  A61K47/48 ,  A61K45/06 ,  G01N33/68 ,  A61K39/395 ,  A61K9/00

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US09441038B2

公开(公告)日：2016-09-13

申请号：US14109606

申请日：2013-12-17

Applicant: AbbVie, Inc.

Inventor： Chengbin Wu ,  Dominic J. Ambrosi ,  Chung-ming Hsieh ,  Tariq Ghayur

IPC: A61K38/00 ,  C07K14/545 ,  C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61K45/06 ,  G01N33/68 ,  A61K9/00

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US09592293B2

公开(公告)日：2017-03-14

申请号：US14101145

申请日：2013-12-09

Applicant: AbbVie Inc.

Inventor： Chengbin Wu ,  Richard W. Dixon ,  Jonathan P. Belk ,  Maria A. Argiriadi ,  Hua Ying ,  Carolyn A. Cuff ,  Terry L. Melim ,  Shankar Kumar ,  Paul R. Hinton ,  Yan Chen

IPC: A61K39/395 ,  A61K45/06 ,  C07K14/47 ,  C07K16/24 ,  A61K38/00

CPC classification number: A61K45/06 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/47 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/481

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

Abstract translation: 本发明包括IL-13结合蛋白。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hIL-13活性有害的病症的人类受试者中。

公开(公告)号：US09447184B2

公开(公告)日：2016-09-20

申请号：US14141317

申请日：2013-12-26

Applicant: AbbVie, Inc.

Inventor： Chengbin Wu ,  Dominic J. Ambrosi ,  Chung-ming Hsieh ,  Tariq Ghayur

IPC: C12P21/08 ,  A61K38/00 ,  C07K14/545 ,  C07K16/24 ,  A61K47/48 ,  A61K45/06 ,  G01N33/68 ,  A61K39/395 ,  A61K9/00

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20140154256A1

公开(公告)日：2014-06-05

申请号：US14177153

申请日：2014-02-10

Applicant: AbbVie, Inc.

Inventor： Chengbin Wu ,  Tariq Ghayur ,  Richard W. Dixon ,  Jochen G. Salfeld

IPC: C07K16/46 ,  C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/42 ,  A61K47/6803 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/2809 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/40 ,  C07K16/46 ,  C07K16/467 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/76 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。

公开(公告)号：US08664367B2

公开(公告)日：2014-03-04

申请号：US13847862

申请日：2013-03-20

Applicant: ABBVIE INC.

Inventor： Chengbin Wu ,  Dominic J. Ambrosi ,  Chung-ming Hsieh ,  Tariq Ghayur

IPC: C12P21/08

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质以及它们在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途， 和组合物。

公开(公告)号：US11344621B2

公开(公告)日：2022-05-31

申请号：US16113027

申请日：2018-08-27

Applicant: AbbVie Inc.

Inventor： Chengbin Wu ,  Richard W. Dixon ,  Jonathan P. Belk ,  Hua Ying ,  Maria A. Argiriadi ,  Carolyn A. Cuff ,  Paul R. Hinton ,  Shankar Kumar ,  Terry L. Melim ,  Yan Chen

IPC: A61K39/395 ,  A61K45/06 ,  C07K14/47 ,  C07K16/24 ,  A61K38/00

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：US10086076B2

公开(公告)日：2018-10-02

申请号：US15457264

申请日：2017-03-13

Applicant: AbbVie Inc.

Inventor： Chengbin Wu ,  Richard W. Dixon ,  Jonathan P. Belk ,  Hua Ying ,  Maria A. Argiriadi ,  Carolyn A. Cuff ,  Paul R. Hinton ,  Shankar Kumar ,  Terry L. Melim ,  Yan Chen

IPC: A61K39/395 ,  A61K45/06 ,  C07K14/47 ,  C07K16/24 ,  A61K38/00

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：US09409986B2

公开(公告)日：2016-08-09

申请号：US14133380

申请日：2013-12-18

Applicant: AbbVie, Inc.

Inventor： Chengbin Wu ,  Dominic J. Ambrosi ,  Chung-ming Hsieh ,  Tariq Ghayur

IPC: A61K38/00 ,  C07K14/545 ,  C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61K45/06 ,  G01N33/68 ,  A61K9/00

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质及其在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途， 和组合物。

公开(公告)号：US20150056202A1

公开(公告)日：2015-02-26

申请号：US14224894

申请日：2014-03-25

Applicant: AbbVie, Inc.

Inventor： Chengbin Wu ,  Tariq Ghayur ,  Richard W. Dixon ,  Jochen G. Salfeld

IPC: C07K16/46 ,  C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/42 ,  A61K47/6803 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/2809 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/40 ,  C07K16/46 ,  C07K16/467 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/76 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。