Invention Grant
US09593129B2 Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
有权
哌啶酮衍生物作为治疗癌症的MDM2抑制剂
- Patent Title: Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
- Patent Title (中): 哌啶酮衍生物作为治疗癌症的MDM2抑制剂
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Application No.: US15008342Application Date: 2016-01-27
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Publication No.: US09593129B2Publication Date: 2017-03-14
- Inventor: Michael D. Bartberger , Ana Gonzalez Buenrostro , Hilary Plake Beck , Xiaoqi Chen , Richard Victor Connors , Jeffrey Deignan , Jason A. Duquette , John Eksterowicz , Benjamin Fisher , Brian M. Fox , Jiasheng Fu , Zice Fu , Felix Gonzalez Lopez De Turiso , Michael W. Gribble, Jr. , Darin J. Gustin , Julie A. Heath , Xin Huang , XianYun Jiao , Michael G. Johnson , Frank Kayser , David John Kopecky , SuJen Lai , Yihong Li , Zhihong Li , Jiwen Liu , Jonathan D. Low , Brian S. Lucas , Zhihua Ma , Lawrence R. McGee , Joel McIntosh , Dustin L. McMinn , Julio C. Medina , Jeffrey Thomas Mihalic , Steven H. Olson , Yosup Rew , Philip M. Roveto , Daqing Sun , Xiaodong Wang , Yingcai Wang , Xuelei Yan , Ming Yu , Jiang Zhu
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen, Inc.
- Current Assignee: Amgen, Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Markus Bergauer
- Main IPC: C07D498/14
- IPC: C07D498/14 ; C07D221/20 ; C07D471/10 ; C07D211/76 ; C07D279/02 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D407/04 ; C07D407/06 ; C07D409/04 ; C07D413/06 ; C07D417/06 ; C07D498/08 ; C07D498/20 ; C07D405/04 ; C07D417/12 ; C07D417/14 ; C07D491/08 ; C07D491/153
Abstract:
The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Public/Granted literature
- US20160137667A1 Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer Public/Granted day:2016-05-19
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