A histology processing cassette comprising a box comprising a compartment for holding a biological tissue sample, the box having a bottom face comprising at least in part a sample support surface and being transmissible to radiation, an open top face, and two side walls, a back wall and a front wall, the box having dimensions greater than a standard size histology processing cassette and comprising a recess in the front wall adapted to receive a standard size cassette which has a front wall comprising a unique identifier for the biological tissue sample such that upon insertion of the standard cassette in the recess the unique identifier on the front wall of the standard cassette is readable.