Invention Grant
- Patent Title: Anti-IL13 antibodies and uses thereof
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Application No.: US13971394Application Date: 2013-08-20
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Publication No.: US09605065B2Publication Date: 2017-03-28
- Inventor: Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Fransisco
- Assignee: GENENTECH, INC.
- Current Assignee: GENENTECH, INC.
- Current Assignee Address: US CA South San Fransisco
- Agency: Jones Day
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/24 ; A61K39/00

Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Public/Granted literature
- US20140105897A1 Novel Anti-IL13 Antibodies and Uses Thereof Public/Granted day:2014-04-17
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