公开(公告)号：US09605065B2

公开(公告)日：2017-03-28

申请号：US13971394

申请日：2013-08-20

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Matthew Moyle ,  Mason Lu ,  Changning Yan ,  Sanjaya Singh ,  Dan Huang

IPC: A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K2039/505 ,  A61K2039/55522 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

公开(公告)号：US20140105897A1

公开(公告)日：2014-04-17

申请号：US13971394

申请日：2013-08-20

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Matthew Moyle ,  Mason Lu ,  Changning Yan ,  Sanjaya Singh ,  Dan Huang

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K2039/505 ,  A61K2039/55522 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

Abstract translation: 本发明涉及对糖基化和非糖基化的人IL13具有特异性和高亲和力结合的抗IL13​​抗体，不结合小鼠IL13，并以约2摩尔比（MAb：IL13）中和人IL13活性 ）。 本发明还涉及这些抗体在治疗IL13介导的疾病中的用途，所述疾病包括过敏性疾病，如过敏性疾病，包括哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹 食物过敏，慢性阻塞性肺疾病，溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和骨质疏松症。

公开(公告)号：US11939396B2

公开(公告)日：2024-03-26

申请号：US16916822

申请日：2020-06-30

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/24 ,  A61K39/00 ,  A61K45/06 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K39/39591 ,  C07K16/244 ,  C12Y304/21059 ,  A61K2039/505 ,  A61K45/06 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US10738131B2

公开(公告)日：2020-08-11

申请号：US15893238

申请日：2018-02-09

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24 ,  A61K39/00

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US10752703B2

公开(公告)日：2020-08-25

申请号：US16544421

申请日：2019-08-19

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  A61K39/00 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20160200805A1

公开(公告)日：2016-07-14

申请号：US15076960

申请日：2016-03-22

Applicant: Genentech, Inc.

Inventor： Michael Fung ,  Mason Lu ,  William N.C. Sun ,  Cecily R.Y. Sun

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6863 ,  G01N33/6893

Abstract: The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5a. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.

Abstract translation: 本发明涉及结合C5和C5a但不阻止C5活化且不阻止C5b活性的抑制剂。 这种抑制剂分子的一个实例是命名为MAb137-26的单克隆抗体，其结合人C5和C5a的共享表位。 这些抑制剂可用于抑制C5a在治疗由过量或不受控制的C5a产生介导的疾病和病症中的活性。 抑制剂分子也可用于诊断检测C5或C5a的存在/不存在或量。

公开(公告)号：US20240368306A1

公开(公告)日：2024-11-07

申请号：US18439879

申请日：2024-02-13

Applicant: Genentech, Inc.

Inventor： Xiaocheng CHEN ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US11434287B2

公开(公告)日：2022-09-06

申请号：US16682773

申请日：2019-11-13

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Matthew Moyle ,  Mason Lu ,  Changning Yan ,  Sanjaya Singh ,  Dan Huang

IPC: A61K39/00 ,  C07K16/24

Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.