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公开(公告)号：US09873734B2
公开(公告)日：2018-01-23
申请号：US13669230
申请日：2012-11-05
Applicant: Genentech, Inc.
Inventor： Sek Chung Fung , Kang Li , Zhengbin Yao
IPC: A61K39/00 , C07K16/18 , C07K14/705 , C07K16/28
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/56 , C07K2317/76 , C07K2319/30
Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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公开(公告)号：US20160002353A1
公开(公告)日：2016-01-07
申请号：US14792236
申请日：2015-07-06
Applicant: Genentech, Inc.
Inventor： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC: C07K16/40
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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公开(公告)号：US20160002352A1
公开(公告)日：2016-01-07
申请号：US14792213
申请日：2015-07-06
Applicant: Genentech, Inc.
Inventor： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC: C07K16/40
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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公开(公告)号：US08956811B2
公开(公告)日：2015-02-17
申请号：US13942421
申请日：2013-07-15
Applicant: Genentech, Inc.
Inventor： Kang Li , Sek Chung Fung , Zhengbin Yao
IPC: C07K16/00 , C07K16/18 , C07K16/28 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/577 , A61K39/00 , A61K39/395
CPC classification number: G01N33/57492 , C07K16/28 , C07K2317/56 , G01N33/574 , G01N33/57488 , G01N2333/705
Abstract: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
Abstract translation: 本发明涉及与人Notch3特异性结合的新型抗体及其在检测和/或诊断Notch3相关疾病如癌症中的用途。 本发明还包括编码这些新型抗体的核酸，携带核酸的载体和细胞系，以及包含用于检测和诊断的抗体的试剂盒。
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公开(公告)号：US20170166630A1
公开(公告)日：2017-06-15
申请号：US15224366
申请日：2016-07-29
Applicant: Genentech, Inc.
Inventor： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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Patent Agency Ranking
公开(公告)号：US09605065B2
公开(公告)日：2017-03-28
申请号：US13971394
申请日：2013-08-20
Applicant: Genentech, Inc.
Inventor： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC: A61K39/395 , C07K16/24 , A61K39/00
CPC classification number: C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
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公开(公告)号：US08753826B2
公开(公告)日：2014-06-17
申请号：US13759613
申请日：2013-02-05
Applicant: Genentech, Inc.
Inventor： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC: G01N33/53
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
Abstract translation: 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US20140105897A1
公开(公告)日：2014-04-17
申请号：US13971394
申请日：2013-08-20
Applicant: Genentech, Inc.
Inventor： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC: C07K16/24
CPC classification number: C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Abstract translation: 本发明涉及对糖基化和非糖基化的人IL13具有特异性和高亲和力结合的抗IL13抗体，不结合小鼠IL13，并以约2摩尔比（MAb：IL13）中和人IL13活性 ）。 本发明还涉及这些抗体在治疗IL13介导的疾病中的用途，所述疾病包括过敏性疾病，如过敏性疾病，包括哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹 食物过敏，慢性阻塞性肺疾病，溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和骨质疏松症。
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9.发明申请NOVEL ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE DETECTION AND DIAGNOSIS OF DISEASE 有权抗新药抗体及其在疾病的检测和诊断中的应用公开(公告)号：US20140057288A1
公开(公告)日：2014-02-27
申请号：US13942421
申请日：2013-07-15
Applicant: GENENTECH, INC.
Inventor： Kang Li , Sek Chung Fung , Zhengbin Yao
IPC: G01N33/574
CPC classification number: G01N33/57492 , C07K16/28 , C07K2317/56 , G01N33/574 , G01N33/57488 , G01N2333/705
Abstract: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
Abstract translation: 本发明涉及与人Notch3特异性结合的新型抗体及其在检测和/或诊断Notch3相关疾病如癌症中的用途。 本发明还包括编码这些新型抗体的核酸，携带核酸的载体和细胞系，以及包含用于检测和诊断的抗体的试剂盒。
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公开(公告)号：US20140335078A1
公开(公告)日：2014-11-13
申请号：US14270848
申请日：2014-05-06
Applicant: Genentech, Inc.
Inventor： Sek Chung Fung , Zhengbin Yao
IPC: C07K16/18 , C12N15/113 , A61K45/06 , A61K38/17 , A61K39/395
CPC classification number: C07K16/18 , A61K38/00 , A61K38/1709 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00 , C12N15/113
Abstract: The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5, C6, C7, C8, C9, or C5b-9.
Abstract translation: 本发明涉及通过施用补体途径抑制剂，特别是替代途径抑制剂来治疗眼部疾病和病症。 眼部疾病包括年龄相关性黄斑变性，糖尿病性视网膜病变和眼血管发生。 一个实施方案包括以全抗体，Fab片段或单结构域抗体的形式施用抗因子D抗体。 可用于本发明方法的其它补体成分抑制剂包括因子H或阻断适当素，因子B，因子Ba，因子Bb，C2，C2a，C3a，C5，C5a，C5，C6，C7，C8的作用的抑制剂 ，C9或C5b-9。
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