A vehicle-wheel bearing device with a sensor of the present invention includes a plurality of sensors, mounted to a vehicle-wheel bearing, for detecting load thereon, and signal processor for processing an output signal therefrom to generate a signal vector, and load calculator for calculating load acting on a wheel based on the signal vector. The load calculator includes: a coefficient conversion processing unit for calculating an actual-state load estimation coefficient MC that is a load estimation coefficient for a state where the bearing is mounted to an actual vehicle, based on a standard load estimation coefficient MB that is a determined standard load estimation coefficient for the bearing; and a load calculation unit for calculating load on the wheel based on the signal vector and the actual-state load estimation coefficient MC calculated by the coefficient conversion processing unit.