- 专利标题： KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
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申请号： US14019241申请日： 2013-09-05
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公开(公告)号： US09629934B2公开(公告)日： 2017-04-25
- 发明人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert Charles Ladner
- 申请人： Dyax Corp.
- 申请人地址： US MA Burlington
- 专利权人： Dyax Corp.
- 当前专利权人： Dyax Corp.
- 当前专利权人地址： US MA Burlington
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; A61K49/22 ; A61K47/48 ; A61K51/08 ; C07K7/08 ; C07K14/52 ; C07K14/71 ; A61K38/00
摘要：
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
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