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公开(公告)号：US20140335082A1
公开(公告)日：2014-11-13
申请号：US14353212
申请日：2012-10-18
Applicant: DYAX CORP.
Inventor： Daniel T. Dransfield
IPC: A61K39/395 , A61K45/06
CPC classification number: A61K39/3955 , A61K31/337 , A61K31/655 , A61K31/7068 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/40 , A61K2300/00
Abstract: Proteins that bind to matrix metalloproteinase 14, combination therapies with such proteins and methods of using such proteins are described.
Abstract translation: 描述了结合基质金属蛋白酶14的蛋白质，与这些蛋白质的组合疗法和使用这些蛋白质的方法。
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2.发明授权KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号：US09446155B2
公开(公告)日：2016-09-20
申请号：US14109508
申请日：2013-12-17
Applicant: Dyax Corp. , BRACCO SUISSE SA
Inventor： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert Charles Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
CPC classification number: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
Abstract translation: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。
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公开(公告)号：US09056138B2
公开(公告)日：2015-06-16
申请号：US14031562
申请日：2013-09-19
Applicant: Bracco Suisse S.A. , Dyax Corp.
Inventor： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC classification number: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
Abstract translation: 本发明提供用于治疗和诊断应用的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US20140205545A1
公开(公告)日：2014-07-24
申请号：US14031562
申请日：2013-09-19
Applicant: Dyax Corp. , Bracco Suisse S.A.
Inventor： Hong FAN , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC classification number: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
Abstract translation: 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号：US10314909B2
公开(公告)日：2019-06-11
申请号：US14353212
申请日：2012-10-18
Applicant: DYAX CORP.
Inventor： Daniel T. Dransfield
IPC: A61K39/395 , A61K45/06 , C07K16/40 , A61K31/337 , A61K31/655 , A61K31/7068 , A61K39/00
Abstract: Proteins that bind to matrix metalloproteinase 14, combination therapies with such proteins and methods of using such proteins are described.
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公开(公告)号：US09845340B2
公开(公告)日：2017-12-19
申请号：US14626188
申请日：2015-02-19
Applicant: Dyax Corp.
Inventor： Daniel T. Dransfield , Aaron K. Sato , Robert Charles Ladner
IPC: C07K7/08 , A61K49/00 , B82Y5/00 , C07K14/475 , A61K51/08 , C07K14/00 , A61K47/60 , A61K47/54 , A61K47/66
CPC classification number: C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
Abstract: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
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公开(公告)号：US09629934B2
公开(公告)日：2017-04-25
申请号：US14019241
申请日：2013-09-05
Applicant: Dyax Corp.
Inventor： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert Charles Ladner
CPC classification number: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
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公开(公告)号：US20150374843A1
公开(公告)日：2015-12-31
申请号：US14689537
申请日：2015-04-17
Applicant: Bracco Suisse S.A , Dyax Corp.
Inventor： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC classification number: A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
Abstract translation: 本发明提供用于治疗和诊断应用的组合物和方法。
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