公开(公告)号：US20210322972A1

公开(公告)日：2021-10-21

申请号：US17102509

申请日：2020-11-24

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Ryan Faucette

IPC: B01L3/00 ,  A61B5/15 ,  A61B5/154 ,  C07K16/40 ,  G01N33/564 ,  G01N33/573 ,  G01N33/96

Abstract: Disclosed herein are evacuated blood collection tubes comprising protease inhibitor cocktails in liquid form and uses thereof for assessing features associated with the contact system in a subject, including the endogenous level of contact system activation, the endogenous level of a drug that targets a component of contact system during treatment, and/or the immunogenicity of such a drug.

公开(公告)号：US20210309741A1

公开(公告)日：2021-10-07

申请号：US17203816

申请日：2021-03-17

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Christopher TenHoor ,  Malini Viswanathan

IPC: C07K16/28 ,  A61K49/00 ,  G01N33/68 ,  A61K39/395 ,  A61K48/00

Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.

公开(公告)号：US20210087293A1

公开(公告)日：2021-03-25

申请号：US17010354

申请日：2020-09-02

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Burt Adelman ,  Yung Chyung ,  Christopher TenHoor ,  Jon A. Kenniston ,  Ryan Faucette ,  Ryan Iarrobino ,  Joseph Biedenkapp

IPC: C07K16/40

Abstract: Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.

公开(公告)号：US20200325469A1

公开(公告)日：2020-10-15

申请号：US16789468

申请日：2020-02-13

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner

IPC: C12N15/10 ,  C07K16/00 ,  C40B40/02

Abstract: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.

公开(公告)号：US10370453B2

公开(公告)日：2019-08-06

申请号：US14969498

申请日：2015-12-15

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Malini Viswanathan

IPC: C07K16/40 ,  G01N33/573 ,  A61K39/00

Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.

公开(公告)号：US20180298110A1

公开(公告)日：2018-10-18

申请号：US15562671

申请日：2016-03-30

Applicant: Dyax Corp. ,  SYNVINA C.V.

Inventor： Yung Chyung ,  Burt Adelman ,  Daniel J. Sexton

IPC: C07K16/40 ,  A61P7/10

Abstract: Provided herein are plasma kallikrein antibodies binding to active plasma kallikrein and methods of using such antibodies in preventing hereditary angioedema attack or reducing the rate of hereditary angioedema attack.

公开(公告)号：US20180118851A1

公开(公告)日：2018-05-03

申请号：US15541066

申请日：2015-12-31

Applicant: Dyax Corp.

Inventor： Stephen R. Comeau ,  Andrew Nixon ,  Niksa Kastrapeli ,  Jon A. Kenniston ,  Gregory P. Conley ,  Shauna Mason ,  Allison P. Lindberg ,  Kristopher Kopacz ,  Burt Adelman

IPC: C07K16/40 ,  C07K16/36 ,  C12N9/64 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/395 ,  A61P7/02 ,  C07K16/36 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/94 ,  C12N9/64

Abstract: Described herein are bispecific antibodies that bind to plasma kallikrein (pKal) and Factor XII and methods of producing and using such bi-specific antibodies for treating diseases or disorders associated with the contact system, e.g., hereditary angioedema or thrombosis. One aspect of the present disclosure is a bispecific antibody, comprising: a first polypeptide that comprises a light chain of a first antibody, the light chain comprising a light chain variable region (VL) and a light chain constant region (CL) (e.g., a kappa light chain or a lambda light chain); and a second polypeptide that comprises a heavy chain of the first antibody, the heavy chain comprising a heavy chain variable region (VH) and a heavy chain constant region (CH).

公开(公告)号：US20180002448A1

公开(公告)日：2018-01-04

申请号：US15706621

申请日：2017-09-15

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Malini Viswanathan

IPC: C07K16/40 ,  A61K49/00 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K49/0004 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92

Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.

公开(公告)号：US09683028B2

公开(公告)日：2017-06-20

申请号：US14557171

申请日：2014-12-01

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward Hirsch Cohen ,  Horacio Gabriel Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C40B40/08 ,  C07K16/00 ,  C12N15/10 ,  C12N15/66 ,  C40B40/02

CPC classification number: C07K16/005 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/622 ,  C12N15/10 ,  C12N15/1037 ,  C12N15/1093 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US20160347845A1

公开(公告)日：2016-12-01

申请号：US15234581

申请日：2016-08-11

Applicant: Acceleron Pharma Inc. ,  Dyax Corp.

Inventor： Ravindra Kumar ,  Asya Grinberg ,  Monique Davies ,  Diana Martik ,  Janja Cosic ,  Rachel Kent ,  David Buckler

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.

Abstract translation: 本公开尤其提供了中和抗体及其与ActRIIB结合并用于其的部分。