- 专利标题: Tamper resistant dosage form comprising an anionic polymer
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申请号: US13223384申请日: 2011-09-01
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公开(公告)号: US09636303B2公开(公告)日: 2017-05-02
- 发明人: Lutz Barnscheid , Sebastian Schwier , Johannes Bartholomäus
- 申请人: Lutz Barnscheid , Sebastian Schwier , Johannes Bartholomäus
- 申请人地址: DE Aachen
- 专利权人: GRUENENTHAL GMBH
- 当前专利权人: GRUENENTHAL GMBH
- 当前专利权人地址: DE Aachen
- 代理机构: Norris McLaughlin & Marcus, P.A.
- 优先权: EP10009125 20100902
- 主分类号: A61K31/485
- IPC分类号: A61K31/485 ; A61K31/135 ; A61P25/04 ; A61K47/34 ; A61K9/20 ; A61K31/137
摘要:
A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); a physiologically acceptable polymer (B) obtainable by polymerization of a monomer composition comprising an ethylenically unsaturated monomer bearing an anionic functional group, in protonated form or a physiologically acceptable salt thereof; a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the polymer (B) and the polyalkylene oxide (C).
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