公开(公告)号：US20230183184A1

公开(公告)日：2023-06-15

申请号：US18102983

申请日：2023-01-30

申请人： Gruenenthal GmbH

发明人： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Anita WEGERT ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC分类号： C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

CPC分类号： C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

摘要： The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20220372041A1

公开(公告)日：2022-11-24

申请号：US17866672

申请日：2022-07-18

申请人： GRUENENTHAL GMBH

发明人： Jo ALEN ,  Florian JAKOB ,  Sebastian KRUEGER ,  Philipp BARBIE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC分类号： C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D471/14 ,  A61P29/00

摘要： The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US11311504B2

公开(公告)日：2022-04-26

申请号：US16502651

申请日：2019-07-03

申请人： Gruenenthal GmbH

发明人： Stefanie Frosch ,  Klaus Linz ,  Klaus Schiene

IPC分类号： A61K31/167 ,  A61K31/407 ,  A61K31/223

摘要： The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient selected from (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient selected from paracetamol and propacetamol.

公开(公告)号：US10829480B2

公开(公告)日：2020-11-10

申请号：US16265080

申请日：2019-02-01

申请人： GRUENENTHAL GMBH

发明人： Sven Kuehnert ,  Rene Michael Koenigs ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder ,  Klaus Schiene ,  Ingo Konetzki

IPC分类号： C07D405/06 ,  C07D235/02 ,  C07D401/06 ,  C07D403/06

摘要： The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20200223840A1

公开(公告)日：2020-07-16

申请号：US16740735

申请日：2020-01-13

申请人： Gruenenthal GMBH

发明人： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Daniela FRIEBE ,  Stephanie HENNEN ,  Philipp BARBIE

IPC分类号： C07D417/14 ,  C07D403/10 ,  C07D471/04 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14

摘要： The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20190106429A1

公开(公告)日：2019-04-11

申请号：US16207854

申请日：2018-12-03

申请人： GRUENENTHAL GMBH

发明人： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC分类号： C07D487/04 ,  C07D409/04 ,  C07D401/02 ,  C07D405/02 ,  C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/06 ,  C07D409/14 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04 ,  C07D413/02

摘要： The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10202345B2

公开(公告)日：2019-02-12

申请号：US14799872

申请日：2015-07-15

申请人： Gruenenthal GmbH

发明人： Anita Wegert ,  Bert Nolte ,  Klaus Linz ,  Stephanie Harlfinger ,  Babette-Yvonne Koegel ,  Paul Ratcliffe ,  Fritz Theil ,  Olga Groeger ,  Birgit Braun

IPC分类号： C07D209/54 ,  C07D405/06 ,  C07D409/04 ,  C07D409/14 ,  C07D209/96

摘要： The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

公开(公告)号：US10189854B2

公开(公告)日：2019-01-29

申请号：US15354358

申请日：2016-11-17

申请人： Grünenthal GmbH

发明人： Antonio Nardi ,  Florian Jakob ,  Ingo Konetzki ,  Tobias Craan ,  Christian Hesslinger ,  Robin Doodeman

IPC分类号： C07D491/107 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/08 ,  C07D487/04 ,  C07D487/10

摘要： The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

公开(公告)号：US20180273491A1

公开(公告)日：2018-09-27

申请号：US15979932

申请日：2018-05-15

申请人： GRUENENTHAL GMBH

发明人： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Anita WEGERT ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC分类号： C07D235/02 ,  C07D405/12 ,  C07D487/04 ,  C07D401/06 ,  C07D403/12 ,  C07D413/12 ,  C07D403/06 ,  C07D401/12 ,  C07D417/06

CPC分类号： C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

摘要： The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US09862719B2

公开(公告)日：2018-01-09

申请号：US14804847

申请日：2015-07-21

申请人： Gruenenthal GmbH

发明人： Claudia Hinze ,  Otto Aulenbacher ,  Bernd Sundermann ,  Stefan Oberboersch ,  Elmar Friderichs ,  Werner Englberger ,  Babette-Yvonne Koegel ,  Klaus Linz ,  Hans Schick ,  Helmut Sonnenschein ,  Birgitta Henkel ,  Valerie Sarah Rose ,  Michael Jonathan Lipkin

IPC分类号： C07D209/58 ,  C07D471/10 ,  C07C59/265 ,  C07C59/255 ,  C07C309/06 ,  C07C309/04 ,  C07D491/107 ,  C07D491/10 ,  C07D493/10 ,  C07D495/10

CPC分类号： C07D471/10 ,  C07C59/255 ,  C07C59/265 ,  C07C309/04 ,  C07C309/06 ,  C07D491/10 ,  C07D491/107 ,  C07D493/10 ,  C07D495/10

摘要： Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.