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    Tamper Resistant Dosage Form Comprising An Anionic Polymer
    3.
    发明申请
    Tamper Resistant Dosage Form Comprising An Anionic Polymer 审中-公开
    包含阴离子聚合物的防篡改剂型

    公开(公告)号：US20120059065A1

    公开(公告)日：2012-03-08

    申请号：US13223358

    申请日：2011-09-01

    申请人： Lutz Barnscheid ,  Sebastian Schwier ,  Johannes Bartholomäus

    发明人： Lutz Barnscheid ,  Sebastian Schwier ,  Johannes Bartholomäus

    IPC分类号： A61K31/135 ,  A61P25/04

    CPC分类号： A61K31/137 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2095

    摘要： A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an anionic polysaccharide (B) obtainable by introducing anionic functional groups, in protonated form or a physiologically acceptable salt thereof, into a polysaccharide; and a polyalkylene oxide (C); wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the anionic polysaccharide (B) and the polyalkylene oxide (C).

    摘要翻译： 一种药物剂型及其使用方法，所述药物剂型具有至少500N的断裂强度，所述剂型含有药理活性成分（A）; 通过将质子化形式的阴离子官能团或其生理上可接受的盐引入多糖中获得的阴离子多糖（B） 和聚环氧烷（C）; 其中药理活性成分（A）存在于包含阴离子多糖（B）和聚环氧烷（C）的控释基质中。

    Tamper-resistant tablet providing immediate drug release
    5.
    发明申请
    Tamper-resistant tablet providing immediate drug release 审中-公开
    防篡改片提供即时药物释放

    公开(公告)号：US20130028970A1

    公开(公告)日：2013-01-31

    申请号：US13559644

    申请日：2012-07-27

    申请人： Sebastian Schwier ,  Marcel Haupts ,  Lutz Barnscheid ,  Jana Pätz

    发明人： Sebastian Schwier ,  Marcel Haupts ,  Lutz Barnscheid ,  Jana Pätz

    IPC分类号： A61K9/20 ,  A61K31/135 ,  A61P25/04

    CPC分类号： A61K9/2081 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K2300/00

    摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of coated particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a physiologically acceptable polymer, preferably a polyalkylene oxide; and form a discontinuous phase within the matrix material; which preferably provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.; and method of using said tablet to treat pain and other conditions.

    摘要翻译： 本发明涉及一种抗篡改片剂，其包含（i）基质材料，其量超过片剂总重量的三分之一; 和（ii）少于所述片剂总重量的三分之二的多个涂覆颗粒; 其中所述颗粒包含药理活性化合物和生理上可接受的聚合物，优选聚环氧烷; 并在基体材料内形成不连续相; 其优选在体外条件下根据Ph.Eur立即释放药理学活性化合物。 以及使用所述片剂治疗疼痛和其他病症的方法。

    Tamper Resistant Dosage Form Comprising An Anionic Polymer
    7.
    发明申请
    Tamper Resistant Dosage Form Comprising An Anionic Polymer 有权
    包含阴离子聚合物的防篡改剂型

    公开(公告)号：US20120065220A1

    公开(公告)日：2012-03-15

    申请号：US13223384

    申请日：2011-09-01

    申请人： Lutz BARNSCHEID ,  Sebastian SCHWIER ,  Johannes BARTHOLOMÄUS

    发明人： Lutz BARNSCHEID ,  Sebastian SCHWIER ,  Johannes BARTHOLOMÄUS

    IPC分类号： A61K31/485 ,  A61K31/135 ,  A61P25/04 ,  A61K47/34

    CPC分类号： A61K9/2031 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/137

    摘要： A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); a physiologically acceptable polymer (B) obtainable by polymerization of a monomer composition comprising an ethylenically unsaturated monomer bearing an anionic functional group, in protonated form or a physiologically acceptable salt thereof; a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the polymer (B) and the polyalkylene oxide (C).

    摘要翻译： 一种药物剂型及其使用方法，所述药物剂型具有至少500N的断裂强度，所述剂型含有药理活性成分（A）; 通过聚合包含具有阴离子官能团的烯属不饱和单体，质子化形式的单体组合物或其生理学上可接受的盐得到的生理上可接受的聚合物（B） 重均分子量至少为200,000g / mol的聚环氧烷（C），其中聚环氧烷（C）的含量为至少20重量％，基于剂型的总重量; 其中药理活性成分（A）存在于包含聚合物（B）和聚环氧烷（C）的控释基质中。