- 专利标题: Method for drug loading hydroxyapatite coated implant surfaces
-
申请号: US14786060申请日: 2014-04-22
-
公开(公告)号: US09662425B2公开(公告)日: 2017-05-30
- 发明人: Mirjam Lilja , Jan Henrik Sörensen , Philip Procter , Hartwig Steckel , Torben Christian Sörensen
- 申请人: Stryker European Holdings I, LLC
- 申请人地址: US MI Kalamazoo
- 专利权人: Stryker European Holdings I, LLC
- 当前专利权人: Stryker European Holdings I, LLC
- 当前专利权人地址: US MI Kalamazoo
- 代理机构: Lerner, David, Littenberg, Krumholz & Mentlik, LLP
- 国际申请: PCT/IB2014/060905 WO 20140422
- 国际公布: WO2014/174437 WO 20141030
- 主分类号: A61L27/32
- IPC分类号: A61L27/32 ; A61L31/16 ; A61C8/00 ; A61L27/54 ; A61L31/08 ; A61C19/06 ; C23C4/12
摘要:
A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60° C. to about 100° C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made according to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof.
公开/授权文献
信息查询
IPC分类: